, Marijke M . Faas , Harry van Goor and A . Titia Lely Gasotransmitters : A Solution for the Therapeutic Dilemma in Preeclampsia ?

Gasotransmitters: a solution for the therapeutic dilemma in preeclampsia?

P reeclampsia complicates 2% to 8% of all pregnancies and is a major contributor to maternal mortality worldwide. The only therapy is delivery, often before term. 1 Nitric oxide, carbon monoxide, and hydrogen sulfide are gasotransmitters that regulate vascular development, vascular tone, and affect antioxidant status. 2 Abnormalities in gasotransmitter signaling and production are linked to hyp...

Danger signals from ATP and adenosine in pregnancy and preeclampsia.

Impaired sodium dependent adaptation of arterial stiffness in formerly preeclamptic women : The RETAP – 1 vascular

Anne Marijn van der Graaf, Nina D. Paauw, Tsjitske J. Toering, Martin Feelisch, Marijke M. Faas, 3 Thomas R. Sutton, Magdalena Minnion, Joop. D. Lefrandt, Sicco A. Scherjon, Arie Franx, Gerjan 4 Navis, A. Titia Lely 5 1 Department of Pathology and Medical Biology, Division of Medical Biology, University of Groningen, University Medical 6 Center Groningen, the Netherlands; 2 Department of Obstet...

From preeclampsia to renal disease: a role of angiogenic factors and the renin-angiotensin aldosterone system?

Complicating up to 8% of pregnancies, preeclampsia is the most common glomerular disease worldwide and remains a leading cause of infant and maternal morbidity and mortality. Although the exact pathogenesis of this syndrome of hypertension and proteinuria is still incomplete, a consistent line of evidence has identified an imbalance of proangiogenic and anti-angiogenic proteins as a key factor ...

Plasma hemopexin activity in pregnancy and preeclampsia.

OBJECTIVE Plasma hemopexin activity, associated with increased vascular permeability, was evaluated in healthy pregnant and non-pregnant women and in pre-eclamptic women. METHODS Hemopexin activity and the hemopexin inhibitor, extracellular ATP, were assayed in plasma from pregnant (n = 10), preeclamptic (n = 9), and non-pregnant women (n = 10) using standard methods. Abdominal fascia tissue ...